Prostaglandins and Medicine 1: 117-120, 1978. OXYGEN REQUIREMENT FOR PROSTAGLANDIN BIOSYNTHESIS
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چکیده
The formation of prostaglandins by vesicular gland cyclooxygenase can be regulated by 02 concentrations below 30 11% (20 mm Hg) with an apparent Km value of about 5 PM. This result suggests that most mammalian tissues might be expected normally to have sufficient 02 for some synthesis, and that only occasionally, would the level of oxygen available within some tissues become marginally inadequate to sustain a high rate of prostaglandin biosynthesis.
منابع مشابه
Accelerative autoactivation of prostaglandin biosynthesis by PGG2.
Received October 24, 1978 Summary : Cyclooxygenase catalysis is stimulated by its product, PGG2, and by other lipid hydroperoxides. The endoperoxide, PGH , was not stimulatory. The results provide a direct demonstration of an essen & ial role for lipid hydroperoxides in prostaglandin biosynthesis, and show how the biosynthetic intermediate PGG2 has a positive accelerative effect. INTRODUCTION A...
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تاریخ انتشار 2003